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Comparison · Analytics
GeneNMF vs Holistics
A side-by-side editorial comparison of GeneNMF and Holistics — release velocity, themes, recent moves, and the top alternatives to consider.
GeneNMF vs Holistics: at a glance
What is GeneNMF?
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
What is Holistics?
Holistics is adding governance to the AI layer it spent the summer building.
Holistics ships small, frequent notes - often one or two sentences - covering three strands at once: AI features in Explore and Chat, as-code control over presentation through AML, and workspace hygiene like file history and dark mode. The August entries turn to the AI layer's edges rather than its capabilities, with an AI user attribute for restricting what the assistant can reach. Several entries are barely a line long, so scope frequently has to be read from the headline.
GeneNMF vs Holistics: editorial side-by-side
GeneNMF
0.0ANALYTICS
GeneNMF rebuilt how it derives meta-programs, changing every result it had produced.
◆ Current state
GeneNMF applies non-negative matrix factorization to single-cell expression data to find gene programs, then consolidates programs recurring across samples into meta-programs. Version 0.6.0 replaced the consolidation method: instead of reducing each program to a gene set and taking a consensus, it retains full gene weight vectors and compares them by cosine similarity. Later releases have built reporting and control around that core — a metaprogram composition matrix showing which samples contributed, custom signature databases for enrichment testing, and the ability to drop meta-programs from results.
◆ Where it's heading
The package is moving from producing meta-programs to letting users interrogate and constrain how they were formed. Composition matrices, the drop function and downsampled similarity heatmaps all serve inspection rather than derivation. The parameters added alongside the 0.6.0 rewrite — specificity weighting, cumulative weight thresholds, confidence defined as the fraction of programs containing a gene — turn what were fixed internal choices into stated, tunable ones.
◆ Prediction
Recent releases have been fixes and compatibility work rather than method changes, so the core approach appears settled. The dependency on an RcppML version not on CRAN is the loose end most likely to force the next release.
Holistics
5.0ANALYTICS
Holistics is adding governance to the AI layer it spent the summer building.
◆ Current state
Holistics ships small, frequent notes - often one or two sentences - covering three strands at once: AI features in Explore and Chat, as-code control over presentation through AML, and workspace hygiene like file history and dark mode. The August entries turn to the AI layer's edges rather than its capabilities, with an AI user attribute for restricting what the assistant can reach. Several entries are barely a line long, so scope frequently has to be read from the headline.
◆ Where it's heading
The AI work has moved through a recognizable sequence: capability first with chart suggestions, then observability with AI Chat Insights for admins, and now access control with an AI-specific user attribute. Alongside it, Holistics keeps pulling presentation into AML - custom charts, theme palettes, currency formats - so the things analysts used to click are versioned as code. File history is the join between the two threads, giving every dashboard, model, and dataset its own restorable timeline.
◆ Prediction
With capability, visibility, and access control now in place for the AI layer, the next step is likely audit or policy depth - logging what the assistant answered against which data - rather than new AI surfaces.
Alternatives to GeneNMF and Holistics
Other Analytics products tracked by Sparkpulse, ranked by recent ship velocity. Each card links to a full editorial trajectory and lets you pivot into a head-to-head comparison with either GeneNMF or Holistics.
Omni
Omni ships weekly, and almost every week the headline item is an AI feature.
silx
silx settles into maintenance a release after its PySide6 migration
Plotly
Plotly is turning its cloud into a metered compute platform with an enterprise on-ramp.
aniread
aniread stops asking you to know which tracker wrote the file
Rho
Rho's release machinery finally produced a stable build — and it shipped no new product.
See all GeneNMF alternatives → · See all Holistics alternatives →
Recent activity from GeneNMF and Holistics
Latest ship moves from both products, interleaved chronologically. ⚡ = editorial spark.
- 2d agoHolisticsAI user attribute restricts AI access to sensitive data
- 16d agoHolisticsCustom currency and unit formats, per field
- 19d agoHolisticsFile history: per-file version timeline and restore
- 22d agoHolisticsCustom charts become AML code with GUI authoring
- 23d agoHolisticsColor palettes can be assigned at the theme level
- 27d agoHolisticsDate-range presets and typed shorthands
- 11mo agoGeneNMFSingle-sample runs fixed; gene weight definition refined
- 1y agoGeneNMFMetaprogram composition exposed and custom signature DBs supported
- 1y agoGeneNMFSimilarity heatmap downsampling and meta-program removal
- 2y agoGeneNMFMeta-programs rebuilt on gene weight vectors and cosine similarity ⚡
- 2y agoGeneNMFFirst stable release published to CRAN
Frequently asked questions
What is the difference between GeneNMF and Holistics?
They serve adjacent needs but don't currently overlap on shipped themes. Holistics is currently shipping more aggressively (velocity 5.0 vs 0.0), with 0 editorial sparks in the last 30 days against 0. See the at-a-glance table above for a side-by-side breakdown of velocity, recent sparks, and editorial themes.
Is GeneNMF better than Holistics?
Sparkpulse doesn't pick a winner — we score release velocity, not feature parity. Holistics is currently shipping more aggressively (velocity 5.0 vs 0.0), with 0 editorial sparks in the last 30 days against 0. For your specific use case, the alternatives sections above list other Analytics products to evaluate alongside.
What are the best alternatives to GeneNMF?
Top GeneNMF alternatives in Analytics are ranked by recent ship velocity. Browse the "GeneNMF alternatives" section above for the current picks, or visit /alternatives/genenmf for the full list with editorial commentary on each.
What are the best alternatives to Holistics?
Top Holistics alternatives in Analytics are ranked by recent ship velocity. Browse the "Holistics alternatives" section above for the current picks, or visit /alternatives/holistics for the full list with editorial commentary on each.